Continuous Flow chemistry for APIs and Intermediates, Part 1 (of 2)

Sponsored by: Cambrex

Focused on:

  • A P I
  • C M O
  • Continuous Flow
  • C D M O
  • Small Molecule

Date: 19 April


Time: 3PM London/10AM New York

The introduction of continuous flow processing has changed the way we conduct chemistry. The oil, solvent and polymer industries have extensively used continuous flow chemistry for decades. However, when considering the fine chemical and pharmaceutical industries, continuous flow chemistry has been primarily used when batch operations are deemed unsuitable or unsafe – and in particular, where high energy chemistry is encountered.

Historically, chemists have been reluctant to embrace continuous flow development, instead preferring to develop processes with test tubes and scaling-up to large volume reactors. This method is often at odds with colleagues who have a chemical engineering background as they are more comfortable with the concept of continuous flow.

Cambrex entered continuous flow processing due to its extensive background in high energy chemistry, specifically nitrations and nitric acid oxidations and dates back to Alfred Nobel in 1896. As a result of their experience in this field, Cambrex will discuss the topic of continuous flow through two webinars.

This webinar will:

  • Provide an introduction to continuous flow processing
  • Provide a brief history of continuous flow at Cambrex
  • Discuss the obstacles to be solved and overcome when implementing continuous flow
  • Conclude with a brief look at the future of continuous flow

The second webinar in this series, will explain where pharmaceutical companies are using continuous flow equipment in synthetic development, in particular in multi-step synthesis from pre-clinical to commercial and how an integrated engineering and chemistry team can be utilised to meet these challenges.

Presented by

Jonathan Knight,

VP, New Product Development - Cambrex

Since joining Cambrex in 1996, Jonathan has had a number of commercial roles, including VP, Sales & Marketing for the Cambrex Innovative Pharmaceutical Business Unit.

In 2012, Jonathan established the Innovative Product Group within Cambrex, which comprises a dedicated team responsible for developing new innovative proprietary products. More recently Jonathan has been involved in New Product Development both for API and drug product and the introduction of new technologies.

Fredrik Stenberg,

Product Manager - Cambrex

Fredrik is the Product Manager at Cambrex Karlskoga, Sweden. Fredrik joined Cambrex in 2005 as a Development Engineer. Since then, Fredrik has had roles in both Production and Project and Product Management. Fredrik was assigned the role of Product Manager in 2013 and holds an MSc in Chemical Engineering.

Key Learning Objectives

  • Introduction to Continuous Flow processing
  • A brief history of Continuous Flow at Cambrex
  • Obstacles to be solved/overcome when implementing continuous flow processing
  • Brief introduction to the future of continuous flow


  • API / Intermediates outsourcing
  • Chemical manufacturing / CMC
  • Sourcing
  • Project managers
  • Suppliers
  • Contract manufacturing managers
  • R&D chemists
  • Process chemists