The Importance of Metabolite Analyzers in Efficient High-Throughput Cell Culture Workflows
With timelines shortening and biologics pipelines growing, a need to generate robust process development methods quickly is essential. An Upstream High-Throughput Biologics Development (HTBD) strategy making use of a Tecan liquid-handling system with Design-of-Experiment (DOE) studies has been developed and implemented at the Devens site of Bristol Myers Squibb to meet this demand. However, we discovered that our previous metabolite analyzer greatly held back the potential of our high-throughput experiments, costing us what no-one can afford: time.
This presentation will be a discussion of the Upstream HTBD strategy at BMS - Devens, the success of this strategy, and how moving from a low-throughput to a high-throughput metabolite analyzer was instrumental for this success. This move effectively increased the number of unique experimental conditions evaluated in a two week period from 96 to 288.
A comparison between the previous and current analyzers will be made, depicting the importance of streamlining HT metabolite sampling workflows to prevent crashes, broken equipment, required replacements/calibrations, downtime, loss of data, and increase throughput. The improvements provided by our current analyzer to our workflow have made for a much more fluid high-throughput experience.
So, if you’re looking for a new approach to improve the efficiency of your DOE designs and high-throughput cell culture workflows, then please register.
Presented by
Erik Vandermark,
Scientist
Graduated from Clarkson University in Potsdam, NY with a BS in Bio-Molecular Science in 2006 and a MS in Basic Science (Molecular Biology focus) in 2013.
In that same year, went to work for SUNY Upstate Medical University in Syracuse, NY doing pharmacology research.
Came to BMS in 2014 working in the Upstream High-Throughput group and has been at BMS ever since.