Webinar: The use of 3D Bioprinting to achieve uniformity and reproducibility of in vitro skin models

Development of a reproducible and standardised in vitro skin model for pharmaceutical and medical applications.

Commercially available tissue-engineered skin has remained elusive despite extensive research because the multi-stratified anisotropic structure is difficult to replicate in vitro using traditional tissue engineering techniques.

In the last few years, bioprinting has opened brand-new opportunities for the production of these models, providing a more efficient approach in terms of precision and homogeneity and offering experimental versatility. Such relevant skin equivalents can be used in regenerative procedures, as robust models in toxicological and cosmetic tests and as a tool in basic biological research. The development of new materials which are compatible with both bioprinting procedures and established biological structures is essential to the growth of the entire field.

In this webinar, we will discuss the potential of 3D printing of biomaterials and cells and maturing them in a bioreactor to create functional skin in the lab. We will discuss the requirements of materials used in bioprinting and introduce a versatile peptide bioink technology and discuss the application of these materials in real research environments. Furthermore, we will present a case study on a recently developed in vitro skin model which utilises synthetically made but biologically active bioinks.

The novel skin model is generated using Regemat3Dâ„¢ extrusion-based bioprinter and Biogelxâ„¢-INK-GFOGER, which offers the advantage of creating a more accurate and standardised skin model. The uniformity and reproducibility achieved combining these technologies mean this novel in vitro skin model has the potential to act as a skin substitute in toxicity testing and potentially form the basis of a future cell therapy application.