QPS and the Department of Anaesthesiology of the University Medical Center Groningen (UMCG) have executed more than 20 studies with CSF Sampling. In this webinar, we will share the details on how to execute CSF Sampling, the pro and cons of cCSF Sampling over single Lumbar Puncture. We will discuss the Safety and Tolerability of cCSF Sampling Procedures. In a few case studies, we will share the results and show the value of this technique.
Timed interval cerebrospinal fluid sampling by indwelling catheterization is a valuable tool for pharmacokinetic and pharmacodynamic assessment of drugs. Unlike a single lumbar puncture (‘spinal tap’) this procedure provides information on the time:response relationship.
This will reveal information on blood brain passage of the drug as well as changes in drug related biomarkers e.g. Alzheimer's disease-sensitive biomarkers. cCSF is an invasive procedure that requires solid medical expertise in order to execute properly and safely. Together with the University Medical Centre Groningen, QPS has developed a standardized research tool than is regularly applied in clinic trials at the QPS clinic in Groningen, The Netherlands.
In this webinar we will share information on the technology used, best practices and potential pitfalls, when using this technique. A Board-certified anaesthesiologist always performs CSF catheterization. He will share the “dos and don’ts” based on his extensive experience with this procedure. Also, the most common side effects will be discussed.
We will present an overview of 4 case studies that show the different applications of the use of cCSF in clinical research. We will discuss the different clinical designs of each of these studies, and how these designs can be applied to and implemented in a SAD or MAD study design. We will also discuss the difference between cCSF and single punctures.
Presented by
Professor Anthony Absalom M.D, PhD,
Professor of Anesthesiology, University Medical Center Groningen, Netherlands
Professor Anthony (Tony) Absalom studied medicine at the University of Cape Town, South Africa, and underwent specialist training in East Anglia and Scotland in the UK. He is currently Professor of Anaesthesiology at the University Medical Center Groningen, Netherlands. His clinical interests have been procedural sedation, anaesthesia for neurosurgery, and intravenous anaesthesia techniques. His research interests are in the domains of pharmacology and neuroscience.
He is an editor of the British Journal of Anaesthesia, past President of the Society for Intravenous Anaesthesia, and a former vice-president of the World Society for Intravenous Anaesthesia.
He is currently Chairman of the Neuroanaesthesia Section of the Dutch Association of Anaesthetists and past-Chair of the General Anaesthesia Scientific Sub-committee of the European Society of Anesthesiology. Over the years, Professor Absalom has assisted QPS with the organisation and conduct of several Phase I studies requiring cerebrospinal fluid sampling.
Izaak Den Daas, PhD,
Director of Patient Studies at QPS Netherlands BV
Izaak Den Daas is an experienced clinical pharmacologist with a demonstrated history of working in the pharmaceuticals and contract research organization (CRO) industry. Izaak brings strong operations professional skills in medical devices, biotechnology, cell culture, research and development and CRO management. His current responsibilities focus on ensuring that the QPS NL (Netherlands) patient clinics are functioning seamlessly, including management and maintenance of the quality system, defining and managing the procurement policies, as well as scientific support by evaluation and design of patient studies.
He is an editor of the British Journal of Anaesthesia, past President of the Society for Intravenous Anaesthesia, and a former vice-president of the World Society for Intravenous Anaesthesia.
He is currently Chairman of the Neuroanaesthesia Section of the Dutch Association of Anaesthetists and past-Chair of the General Anaesthesia Scientific Sub-committee of the European Society of Anesthesiology. Over the years, Professor Absalom has assisted QPS with the organisation and conduct of several Phase I studies requiring cerebrospinal fluid sampling.